Postdoctoral fellow position https://ppp.hs.pitt.edu/ViewPost.aspx?q=1147
A postdoctoral fellow position is available to study the molecular mechanisms underlying neuromuscular phenotypes and development of genomic-based therapeutic approaches in rare diseases. The fellow will be working with a team led by Dr. Dwi U. Kemaladewi, Assistant Professor in the Department of Pediatrics, University of Pittsburgh School of Medicine, and the UPMC Children’s Hospital of Pittsburgh (https://www.pediatrics.pitt.edu/people/dwi-u-kemaladewi-phd). The newly-established laboratory offers a unique opportunity to grow your scientific independence, maturity, and curiosity.
Candidates must have (or be near to completing) a PhD, with a proven track record of successful training as demonstrated by first author publication(s). We are looking for a highly motivated and interactive colleague with a strong genetics background.
Experience working with mouse models of disease and/or experimental therapeutics, including but not limited to siRNA, antisense oligonucleotides, CRISPR/Cas, viral vectors are highly preferred.
Several projects are available immediately based on the following work:
1. A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene
(Kemaladewi*, Bassi*, et al, Nature, 2019).
2. Increased polyamines as protective disease modifiers in congenital muscular dystrophy
(Kemaladewi et al, Human Molecular Genetics, 2018).
3. Correction of a splicing defect in a mouse model of CMD type 1A using a HDR-independent mechanism
(Kemaladewi et al, Nature Medicine, 2017).
4. Spell-Checking nature: Versatility of CRISPR/Cas9 for developing treatments for inherited disorders
(Wojtal*, Kemaladewi*, et al, American Journal of Human Genetics, 2016).
In addition, the candidates will be encouraged to apply their knowledge and propose a project that can complement the strength and collaborative environment within the Division of Medical Genetics (https://www.pediatrics.pitt.edu/division-medical-genetics). A topic of interest includes the contribution of energy/metabolic dysfunctions to pediatric diseases (broadly-defined).
The University of Pittsburgh and UPMC Children’s Hospital of Pittsburgh, rank in the top 5 of NIH funding and top 10 of Best Children’s Hospitals in the nation, offer an intensive yet collaborative biomedical research environment. The Kemaladewi Lab is affiliated with the Graduate School of Public Health, Center for Rare Disease Therapy, and Richard King Mellon Foundation for Pediatric Research, which offer outstanding scientific and career development opportunities.
Interested applicants should submit a complete CV, a description of their research interests, achievements, and career goals, and the contact details of three referees to: firstname.lastname@example.org. Only shortlisted candidates will be contacted and invited for interviews.